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KMID : 0903520040470030357
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2004 Volume.47 No. 3 p.357 ~ p.360
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Development of Biologically Active Compounds from Edible Plant Sources-X. Isolation of Lipids from the Flower of Campsis grandiflora K. Schum. and their Inhibitory Effect on FPTase
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Kim Dong-Hyun
Song Myoung-Chong
Han Kyung-Min
Bang Myun-Ho
Kwon Byoung-Mog
Kim Sung-Hoon
Kim Dae-Keun
Chung In-Sik
Park Mi-Hyun
Baek Nam-In
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Abstract
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The flower of Campsis grandiflora K. Schum. was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. From the EtOAc fraction, four compounds were isolated through the repeated silica gel and ODS column chromatographies. From the result of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as linolenic acid methyl ester, linoleic acid methyl ester, β-sitosterol and daucosterol. Daucosterol inhibited FPTase activity with IC50 values of 140.04 μM.
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KEYWORD
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Campsis grandiflora K. Schum., linoleic acid, linolenic acid, β-sitosterol, daucosterol, FPTase
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